WNT10A

WNT10A
Identifiers
Aliases	WNT10A, OODD, SSPS, STHAG4, Wnt family member 10A
External IDs	OMIM: 606268; MGI: 108071; HomoloGene: 22525; GeneCards: WNT10A; OMA:WNT10A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,899,581 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,843,338 bp
RNA expression pattern
	Top expressed in
	gonad; ; bone marrow cell; ; skin of abdomen; ; skin of leg; ; granulocyte; ; lymph node; ; pituitary gland; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; anterior pituitary;
	Top expressed in
	tooth; ; molar; ; prostatic epithelium; ; inner root sheath; ; gastrula; ; epithelium of male urethra; ; enamel knot; ; lip; ; urethral gland (male); ; corneal stroma;
	More reference expression data
	n/a
Gene ontology
Molecular function	frizzled binding; signaling receptor binding; receptor ligand activity;
Cellular component	extracellular region; extracellular space;
Biological process	skin development; odontogenesis; tongue development; hair follicle development; positive regulation of gene expression; regulation of odontogenesis of dentin-containing tooth; multicellular organism development; neural crest cell differentiation; neuron differentiation; epidermis morphogenesis; hair follicle morphogenesis; cell fate commitment; cellular response to transforming growth factor beta stimulus; sebaceous gland development; Wnt signaling pathway; regulation of signaling receptor activity; canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	80326
	22409
	ENSG00000135925
	ENSMUSG00000026167
	Q9GZT5
	P70701
	NM_025216
	NM_009518
	NP_079492
	NP_033544
	Wikidata
View/Edit Human	View/Edit Mouse

Wnt-10a is a protein that in humans is encoded by the WNT10A gene.^[5]^[6]^[7]

Function

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family.^[5]

Clinical significance

WNT10A is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.^[5]

Mutations in the WNT10A gene are associated with Schöpf–Schulz–Passarge syndrome,^[8] hypodontia,^[9] and short anagen hair syndrome.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135925 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026167 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c "Entrez Gene: wingless-type MMTV integration site family".
^ Kirikoshi H, Sekihara H, Katoh M (May 2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochemical and Biophysical Research Communications. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055.
^ Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, et al. (October 2007). "Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia". American Journal of Human Genetics. 81 (4): 821–828. doi:10.1086/520064. PMC 1973944. PMID 17847007.
^ Bohring A, Stamm T, Spaich C, Haase C, Spree K, Hehr U, et al. (July 2009). "WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes". American Journal of Human Genetics. 85 (1): 97–105. doi:10.1016/j.ajhg.2009.06.001. PMC 2706962. PMID 19559398.
^ van den Boogaard MJ, Créton M, Bronkhorst Y, van der Hout A, Hennekam E, Lindhout D, et al. (May 2012). "Mutations in WNT10A are present in more than half of isolated hypodontia cases" (PDF). Journal of Medical Genetics. 49 (5): 327–331. doi:10.1136/jmedgenet-2012-100750. PMID 22581971. S2CID 8815004. Archived from the original (PDF) on 2018-07-23. Retrieved 2019-02-16.
^ Cesarato N, Schwieger-Briel A, Gossmann Y, Henne SK, Hillmann K, Frommherz LH, et al. (November 2023). "Short anagen hair syndrome: association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss". The British Journal of Dermatology. 189 (6): 741–749. doi:10.1093/bjd/ljad314. hdl:20.500.11811/11578. PMID 37671665.

Gelebart P, Anand M, Armanious H, Peters AC, Dien Bard J, Amin HM, et al. (December 2008). "Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma". Blood. 112 (13): 5171–5179. doi:10.1182/blood-2008-02-139212. PMC 2597612. PMID 18787224.
Beaty TH, Hetmanski JB, Fallin MD, Park JW, Sull JW, McIntosh I, et al. (November 2006). "Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations". Human Genetics. 120 (4): 501–518. doi:10.1007/s00439-006-0235-9. PMID 16953426. S2CID 7836461.
Nawaz S, Klar J, Wajid M, Aslam M, Tariq M, Schuster J, et al. (December 2009). "WNT10A missense mutation associated with a complete odonto-onycho-dermal dysplasia syndrome". European Journal of Human Genetics. 17 (12): 1600–1605. doi:10.1038/ejhg.2009.81. PMC 2987016. PMID 19471313.

Medland SE, Nyholt DR, Painter JN, McEvoy BP, McRae AF, Zhu G, et al. (November 2009). "Common variants in the trichohyalin gene are associated with straight hair in Europeans". American Journal of Human Genetics. 85 (5): 750–755. doi:10.1016/j.ajhg.2009.10.009. PMC 2775823. PMID 19896111.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, et al. (December 2009). "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men". Journal of Bone and Mineral Research. 24 (12): 2039–2049. doi:10.1359/jbmr.090524. PMC 2791518. PMID 19453261.
Memarian A, Hojjat-Farsangi M, Asgarian-Omran H, Younesi V, Jeddi-Tehrani M, Sharifian RA, et al. (December 2009). "Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia". Leukemia & Lymphoma. 50 (12): 2061–2070. doi:10.3109/10428190903331082. PMID 19863181. S2CID 38835813.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135925 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026167 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: wingless-type MMTV integration site family".

[pmid11350055-6] Kirikoshi H, Sekihara H, Katoh M (May 2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochemical and Biophysical Research Communications. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055.

[pmid17847007-7] Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, et al. (October 2007). "Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia". American Journal of Human Genetics. 81 (4): 821–828. doi:10.1086/520064. PMC 1973944. PMID 17847007.

[pmid19559398-8] Bohring A, Stamm T, Spaich C, Haase C, Spree K, Hehr U, et al. (July 2009). "WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes". American Journal of Human Genetics. 85 (1): 97–105. doi:10.1016/j.ajhg.2009.06.001. PMC 2706962. PMID 19559398.

[pmid22581971-9] van den Boogaard MJ, Créton M, Bronkhorst Y, van der Hout A, Hennekam E, Lindhout D, et al. (May 2012). "Mutations in WNT10A are present in more than half of isolated hypodontia cases" (PDF). Journal of Medical Genetics. 49 (5): 327–331. doi:10.1136/jmedgenet-2012-100750. PMID 22581971. S2CID 8815004. Archived from the original (PDF) on 2018-07-23. Retrieved 2019-02-16.

[10] Cesarato N, Schwieger-Briel A, Gossmann Y, Henne SK, Hillmann K, Frommherz LH, et al. (November 2023). "Short anagen hair syndrome: association with mono- and biallelic variants in WNT10A and a genetic overlap with male pattern hair loss". The British Journal of Dermatology. 189 (6): 741–749. doi:10.1093/bjd/ljad314. hdl:20.500.11811/11578. PMID 37671665.

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v t e Signaling pathway: Wnt signaling pathway
Ligand	WNT1 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WNT10A WNT10B WNT11 WNT16
Receptor	Frizzled LRP5 LRP6
Second messenger	Dishevelled GSK-3 APC β-catenin

Function

Clinical significance

References

Further reading