Taxifolin 8-monooxygenase
| Taxifolin 8-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.19 | ||||||||
| CAS no. | 39307-19-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Taxifolin 8-monooxygenase (EC 1.14.13.19) is an enzyme that catalyzes the chemical reaction
-Taxifolin.svg)
The four substrates of this enzyme are taxifolin, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are dihydrogossypetin, oxidised NAD+, and water. Nicotinamide adenine dinucleotide phosphate can be used as an alternative cofactor.[1][2]
The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is phenol,NADPH:oxygen oxidoreductase (2-hydroxylating). Other names in common use include phenol hydroxylase, and phenol o-hydroxylase. It uses flavin adenine dinucleotide as a second cofactor. The systematic name of this enzyme class is taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating). This enzyme is also called taxifolin hydroxylase.[1]
References
[edit]- ^ a b Enzyme 1.14.13.19 at KEGG Pathway Database.
- ^ Jeffrey AM, Knight M, Evans WC (1972). "The bacterial degradation of flavonoids. Hydroxylation of the A-ring of taxifolin by a soil pseudomonad". Biochem. J. 130 (2): 373–81. doi:10.1042/bj1300373. PMC 1174416. PMID 4146277.
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