Talk:Long non-coding RNA

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LncRNAs regulated by transcription factors

As of now this section is purely self-promotional — Preceding unsigned comment added by 84.88.66.194 (talk) 16:25, 26 March 2014 (UTC)[reply]

Moving to long non-coding RNA

Moving 'long noncoding RNA' to 'long non-coding RNA' (with hypen). This then conforms with non-coding RNA and is (marginally) more commonly seen in the literature, see pubmed searches for hyphenated (596) vs unhyphenated (522)^{numbers correct as of 10:56, 13 September 2010 (UTC)} Jebus989^✰ 10:56, 13 September 2010 (UTC)[reply]

RE: Long ncRNAs in translation

I found out that the BC1 is 167 nucleotides long i.e. shorter than 200nt threshold. Here is the link: http://www.ncbi.nlm.nih.gov/nuccore/NR_033762.1

Why do we consider it as LONG non-coding RNA? Dmanagadze (talk) 16:24, 26 October 2010 (UTC)[reply]

Some LncRNAs are conventional

New research has found that some LncRNA can give rise to peptides. Link here: http://www.ncbi.nlm.nih.gov/pubmed/24705786 — Preceding unsigned comment added by 81.153.227.206 (talk) 23:06, 30 October 2014 (UTC)[reply]

I don't know who started this topic, but based on a Nature paper in 2017 I added discussion about translation of lncRNAs DennisPietras (talk) 02:25, 14 January 2017 (UTC)[reply]

2017 database with accurate 5' ends

Comprehensive Atlas of Long Noncoding RNAs Yields Surprising New Role says "The atlas, which contains 27,919 lncRNAs, summarizes for the first time their expression patterns across major human cell types and tissues. By intersecting this atlas with genomic and genetic data, their results suggest that 19,175 of these RNAs may be functional, ..." - Rod57 (talk) 18:34, 4 March 2017 (UTC)[reply]

Long noncoding RNAs for a new class of anti-inflamation drugs

The peer-reviewed article is Human and mouse long noncoding RNAs reengineered for exogenous delivery reduce LPS-induced inflammation in human macrophages and mice, Science Signaling, 10 Mar 2026, Vol 19, Issue 928. Free access via Wiki Library.

Science Advisor newsletter (11 March 2026): "With more than 35,000 lncRNAs catalogued in the human transcriptome, the vast majority of which have unknown functions, the findings open what the authors describe as an entirely new drug modality. Unlike conventional small molecules or biologics, these molecules are already shaped by evolution to operate inside cells with high specificity, a property the authors say could reduce the risk of side effects compared to existing treatments. “ This is a completely new paradigm for drug discovery,” senior author Omar Khan told Inside Precision Medicine . “The dark transcriptome is a great opportunity to find new treatments that will really change lives in the future.” Pete Tillman (talk) 14:37, 11 March 2026 (UTC)[reply]