Protoporphyrinogen IX
 | |
| Identifiers | |
|---|---|
3D model (JSmol)
|
|
| ChEBI | |
| ChemSpider | |
| MeSH | protoporphyrinogen |
PubChem CID
|
|
CompTox Dashboard (EPA)
|
|
| |
| |
| Properties | |
| C34H38N4O4 | |
| Molar mass | 566.7 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Protoporphyrinogen IX is an organic chemical compound which is produced along the synthesis of porphyrins, a class of critical biochemicals that include hemoglobin and chlorophyll. It is a direct precursor of protoporphyrin IX.
The compound is a porphyrinogen, meaning that it has a non-aromatic hexahydroporphine core, which will be oxidized to a porphine core in later stages of the heme synthesis. Like most porphyrinogens, it is colorless.[citation needed]
Biosynthesis
[edit]The compound is synthesized in most organisms from coproporphyrinogen III by the enzyme coproporphyrinogen oxidase:[1]
The process entails conversion of two of four propionic acid groups to vinyl groups.[2]
By the action of protoporphyrinogen oxidase, protoporphyrinogen IX is later converted into protoporphyrin IX, the first colored tetrapyrrole in the biosynthesis of hemes.[3][4]
References
[edit]- ^ Enzyme 1.3.3.3 at KEGG Pathway Database.
- ^ Kohno H, Furukawa T, Yoshinaga T, Tokunaga R, Taketani S (October 1993). "Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation". The Journal of Biological Chemistry. 268 (28): 21359–63. doi:10.1016/S0021-9258(19)36931-5. PMID 8407975.
- ^ Paul R. Ortiz de Montellano (2008). "Hemes in Biology". Wiley Encyclopedia of Chemical Biology. John Wiley & Sons. pp. 1–10. doi:10.1002/9780470048672.wecb221. ISBN 978-0470048672.
- ^ Enzyme 1.3.3.4 at KEGG Pathway Database.
 | This article about an organic compound is a stub. You can help Wikipedia by adding missing information. |