Draft:Ailurus Bio
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Comment: Please check WP:GNG and WP:NPOV. Note about the sources: Nearly all citations are a) primary/self-published, b) directory/event listings, or c) scientific sources about the underlying research rather than independent, in-depth coverage of the company itself.Aeon Sentinel (talk) 15:04, 25 September 2025 (UTC)
Ailurus Bio is a biotechnology company that develop biological programs[1], or "bioprograms", genetic codes that instruct biological processes and have been described as "living software".[2] The company has stated that it aims to "make biology a general‑purpose technology", "as easy to use as modern computers", and to develop "biocomputers" with standardized architectures and programming language.[3] The company's name refers to the red panda (genus Ailurus).
History
[edit]"Ailurus" was first used as a brand of Xunzhu Biotechnology Co., Ltd., a synthetic biology platform company, co‑founded by Haotian Guo and Jiang Shan in Shenzhen, China, in 2020.[4]
In October 2022, Cell published work by Guo and colleagues on TEARS, an RNA‑based system that forms liquid‑like compartments in bacteria that can act as organelle‑like scaffolds[5][6][7][8]. TEARS was first introduced as "RNA organelles" by Paris Bettencourt iGEM team led by Guo at INSERM and Center for Research and Interdisciplinarity in 2017, which was the first public record of liquid-liquid phase separation system in bacteria.[6]
Ailurus Bio Ltd was incorporated in the United Kingdom on 31 October 2022 as a separate legal entity,[9] is based in London,[10] and began by commercializing TEAR‑2, a development kit for phase separation.[7][8]
In 2024, the company announced PandaPure,[11][12] a system that enables protein purification with synthetic organelle, eliminating the need for chromatography or other resin-dependent methods.
Research
[edit]The company reports conducting research on phase separation[7][8], and design of new molecules. Building on earlier work in machine-learning guided evolution of antimicrobial peptides,[13][14] and AI‑designed anti‑CRISPR RNA,[15] the company also develops its capacity to support closed‑loop of wet‑lab data acquisition and AI‑assisted design.[16][17]
References
[edit]- ^ "Ailurus Bio - Program biology as your copilot". www.ailurus.bio. Retrieved 2025-09-01.
- ^ Dunn, Sara-Jane (2019-11-01). The next software revolution: programming biological cells. Retrieved 2025-09-01 – via www.ted.com.
- ^ "New Technologies - White City Innovation District". 2024-01-08. Retrieved 2025-09-01.
- ^ "Ailurus Biotechnology 2025 Company Profile: Valuation, Funding & Investors | PitchBook". pitchbook.com. Retrieved 2025-09-01.
- ^ Guo, Haotian; Ryan, Joseph C.; Song, Xiaohu; Mallet, Adeline; Zhang, Mengmeng; Pabst, Victor; Decrulle, Antoine L.; Ejsmont, Paulina; Wintermute, Edwin H.; Lindner, Ariel B. (2022-09-29). "Spatial engineering of E.coli with addressable phase-separated RNAs". Cell. 185 (20): 3823–3837.e23. doi:10.1016/j.cell.2022.09.016. ISSN 1097-4172. PMID 36179672.
- ^ a b Barnes, Natalie G. (2022-11-08). "Organelle-like scaffolds in bacteria for synthetic biology". Nature Biotechnology. 40 (11): 1574. doi:10.1038/s41587-022-01569-8. ISSN 1546-1696. PMID 36347988.
- ^ a b c PhD, Jonathan D. Grinstein (2024-03-01). "What's in Vogue for SynBio's Retooling of Nature's Code?". GEN - Genetic Engineering and Biotechnology News. Retrieved 2025-09-01.
- ^ a b c Ball, Philip. "A promising breakthrough in liquid condensate compartmentalisation". Chemistry World. Retrieved 2025-09-01.
- ^ "AILURUS LTD overview - Find and update company information - GOV.UK". find-and-update.company-information.service.gov.uk. Retrieved 2025-09-01.
- ^ "New Technologies - White City Innovation District". 2024-01-08. Retrieved 2025-09-01.
- ^ "A Vision for the Future of Biomanufacturing: Highlights from Shanghai's Precision Fermentation Forum - SynBioBeta". www.synbiobeta.com. Retrieved 2025-09-01.
- ^ "Innovation Collaboration Day 2024". www.basf.com. Retrieved 2025-09-01.
- ^ "Team:Paris Bettencourt/AMPDesigner Overview - 2018.igem.org". 2018.igem.org. Retrieved 2025-09-01.
- ^ "Dry Lab Impulse #7: Paris-Bettencourt'18 - Software for AMP design, optimization, prediction". iGEM Video Universe. Retrieved 2025-09-01.
- ^ Guo, Haotian; Song, Xiaohu; Lindner, Ariel B. (2020-12-01). "Anti-CRISPR RNAs: designing universal riboregulators with deep learning of Csy4-mediated RNA processing". bioRxiv 10.1101/2020.11.15.384107.
- ^ "2023 GSBC session - Lightning Talk (SynBioBeta). Ailurus Protein Service: next-generation protein engineering at a massive scale". www.synbiobeta.com. Retrieved 2025-09-01.
- ^ "The State of AI at SynBioBeta 2024 - SynBioBeta". www.synbiobeta.com. Retrieved 2025-09-01.
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