7-Methylxanthine demethylase
| 7-Methylxanthine demethylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.128 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
7-Methylxanthine demethylase (EC 1.14.13.128) is an enzyme with systematic name 7-methylxanthine:oxygen oxidoreductase (demethylating).[1] This enzyme catalyses the following chemical reaction
The four substrates of this enzyme are 7-methylxanthine, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are xanthine, oxidised NAD+, water, and formaldehyde.[2]
The enzyme is a non-heme iron protein that is part of the pathway of caffeine degradation in Pseudomonas putida.[3]
References
[edit]- ^ Summers, Ryan M.; Louie, Tai Man; Yu, Chi Li; Subramanian, Mani (2011). "Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids as sole carbon and nitrogen source". Microbiology. 157 (2): 583–592. doi:10.1099/mic.0.043612-0. PMID 20966097.
- ^ Enzyme 1.14.13.128 at KEGG Pathway Database.
- ^ Summers, Ryan M.; Louie, Tai Man; Yu, Chi-Li; Gakhar, Lokesh; Louie, Kailin C.; Subramanian, Mani (2012). "Novel, Highly Specific N -Demethylases Enable Bacteria to Live on Caffeine and Related Purine Alkaloids". Journal of Bacteriology. 194 (8): 2041–2049. doi:10.1128/JB.06637-11. PMC 3318484. PMID 22328667.
External links
[edit]- 7-methylxanthine+demethylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
