2-hydroxyquinoline 8-monooxygenase
| 2-hydroxyquinoline 8-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.61 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
2-hydroxyquinoline 8-monooxygenase (EC 1.14.13.61) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are 2-hydroxyquinoline, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are 2,8-dihydroxyquinoline, oxidised NAD+, and water.[1][2]
The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating). This enzyme is also called 2-oxo-1,2-dihydroquinoline 8-monooxygenase. It is an iron–sulfur protein.[1][2]
Structural studies
[edit]As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1Z01, PDB: 1Z02, and PDB: 1Z03.
References
[edit]- ^ a b Enzyme 1.14.13.61 at KEGG Pathway Database.
- ^ a b Rosche B, Tshisuaka B, Fetzner S, Lingens F (1995). "2-Oxo-1,2-dihydroquinoline 8-monooxygenase, a two-component enzyme system from Pseudomonas putida 86". J. Biol. Chem. 270 (30): 17836–42. doi:10.1074/jbc.270.30.17836. PMID 7629085.
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