(R)-limonene 6-monooxygenase
| (R)-limonene 6-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.53 | ||||||||
| CAS no. | 221461-49-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
(R)-limonene 6-monooxygenase (EC 1.14.14.53) is an enzyme that catalyzes the chemical reaction
-Limonen.svg)
The four substrates of this enzyme are (+)-(R)-limonene, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are (+)-trans-carveol, oxidised NADP+, and water.[1][2]
This enzyme is a cytochrome P450 protein containing heme. This oxidoreductase, which uses molecular oxygen as oxidant, is in a group with systematic name (R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating). Other names in common use include (+)-limonene-6-hydroxylase, and (+)-limonene 6-monooxygenase.[1] It is part of the biosynthesis pathway to (+)-carvone in caraway.[3]
See also
[edit]- CYP2C19
- (S)-limonene 6-monooxygenase which converts the opposite enantiomer of limonene to (–)-trans-carveol
References
[edit]- ^ a b Enzyme 1.14.14.53 at KEGG Pathway Database.
- ^ Bouwmeester HJ, Gershenzon J, Konings MC, Croteau R (1998). "Biosynthesis of the monoterpenes limonene and carvone in the fruit of caraway. I. Demonstration Of enzyme activities and their changes with development". Plant Physiol. 117 (3): 901–12. doi:10.1104/pp.117.3.901. PMC 34944. PMID 9662532.
- ^ Croteau R (1999). "Cytochrome P-450 dependent (+)-limonene-6-hydroxylation in fruits of caraway (Carum Carvi)". Phytochemistry. 50 (2): 243–248. doi:10.1016/S0031-9422(98)00516-0.
