α-Mannosidase
(Redirected from Alpha-mannosidase)
| α-Mannosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 α-Mannosidase 1, tetramer, Saccharomyces cerevisiae | |||||||||
| Identifiers | |||||||||
| EC no. | 3.2.1.24 | ||||||||
| CAS no. | 9025-42-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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α-Mannosidase (EC 3.2.1.24, α-D-mannosidase, p-nitrophenyl-α-mannosidase, α-D-mannopyranosidase, 1,2-α-mannosidase, 1,2-α-D-mannosidase, exo-α-mannosidase) is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase.[3][4]
Isoenzymes
[edit]Humans express the following three α-mannosidase isoenzymes:
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Applications
[edit]It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.[5]
Pathology
[edit]A deficiency can lead to α-mannosidosis.[6]
References
[edit]- ^ "PyMol". Schrodinger. Retrieved 2011-09-14.
- ^ Suits MD, Zhu Y, Taylor EJ, Walton J, Zechel DL, Gilbert HJ, et al. (February 2010). "Structure and kinetic investigation of Streptococcus pyogenes family GH38 alpha-mannosidase". PLOS ONE. 5 (2) e9006. Bibcode:2010PLoSO...5.9006S. doi:10.1371/journal.pone.0009006. PMC 2815779. PMID 20140249.
- ^ Li YT (February 1966). "Presence of alpha-D-mannosidic linkage in glycoproteins. Liberation of d-mannose from various glycoproteins by alpha-mannosidase isolated from jack bean meal". The Journal of Biological Chemistry. 241 (4): 1010–1012. doi:10.1016/S0021-9258(18)96865-1. PMID 5905120.
- ^ Winchester B (June 1984). "Role of alpha-D-mannosidases in the biosynthesis and catabolism of glycoproteins". Biochemical Society Transactions. 12 (3): 522–524. doi:10.1042/bst0120522. PMID 6428944.
- ^ Vlahopoulos S, Gritzapis AD, Perez SA, Cacoullos N, Papamichail M, Baxevanis CN (July 2009). "Mannose addition by yeast Pichia Pastoris on recombinant HER-2 protein inhibits recognition by the monoclonal antibody herceptin". Vaccine. 27 (34): 4704–4708. doi:10.1016/j.vaccine.2009.05.063. PMID 19520203.
- ^ Malm D, Nilssen Ø (July 2008). "Alpha-mannosidosis". Orphanet Journal of Rare Diseases. 3 21. doi:10.1186/1750-1172-3-21. PMC 2515294. PMID 18651971.
External links
[edit]- GeneReviews/NCBI/NIH/UW entry on Alpha-Mannosidosis
- OMIM entries on Alpha-Mannosidosis
- alpha-Mannosidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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